G beta:gamma signalling through PI3Kgamma

PI3K gamma (PI3KG) is a heterodimer consisting of a p110 catalytic subunit associated with a regulatory p101 or p84 subunit. PI3KG is most highly expressed in neutrophils, where the p101 form predominates (approximately 95%). G beta:gamma recruits PI3KG to the plasma membrane, both activating PI3KG and providing access to its substrate PIP2, which is converted to PIP3.

PI3K gamma（PI3KG）是一种由与调节性亚基p101或p84相结合的p110催化亚基组成的异源二聚体。PI3KG在嗜中性粒细胞中表达最为显著，其中p101型占主导地位（约为95%）。G beta:gamma能够将PI3KG招募至质膜，从而激活PI3KG，并提供其底物PIP2的访问途径，PIP2随后被转化为PIP3。