The effect of trial design on effect size with an assumed trial drug efficacy of 80% reduction in seizure burden for 12h.

Outcome measures (OM) are total seizure burden (tSB) in minutes, post-intervention seizure burden (pSB) in minutes measured over a duration specified by the subscript in hours, seizure burden response (rSB) in minutes per hour, 1h pre-intervention vs. a post-intervention duration specified by the subscript in hours. The maximum possible effect for each trial is given in the Table 4. The effect size of tSB and pSB12 are equal as the assumed efficacy of the trial AED effect is 12h. The effect size of pSB1 and rSB1 are also equal as the rSB is measured in minutes per hour and not as a proportion. Results are presented as effect size (95% CI).