Transcriptomic profiling of compensated and decompensated human right ventricles. Transcriptomic profiling of compensated and decompensated human right ventricles

In order to better understand the molecular mechanisms underlying right ventricular failure in human PAH, a RNA sequencing analysis was performed in RV tissues obtained from subjects clinically categorized as compensated RV (n=11), decompensated RV (n=7) and donor controls (n=14). The study unveils a plethora of factors dysregulated in the RV of PAH patients, which opens new perspectives for translational research. Overall design: mRNA profiles for control, compensated and decompensated human right ventricle