Protective effects of immunization with plasmid membrane-anchored pIRES-sjFABP-sj26GST, secreted pIRES-sjFABP-sj26GST, and pIRES following S. japonicum challenge in BALB/c mice.

All results are presented as mean ± SD. The mice were vaccinated with 100 µg membrane-anchored pIRES-sjFABP-sj26GST, secreted pIRES-sjFABP-sj26GST, and pIRES plasmid twice with a 3-week interval. Two weeks after final boosting, all groups were infected with 40±1 S. japonicum cercariae. Mice were euthanized 45 days after challenge at which point adult worm burdens and egg numbers in feces and liver were compared among the 3 groups.*Results were statistically significant when compared to the PIRES group (P**Results were statistically significant when compared to the pIRES-sjFABP-sj26GST membrane-anchored group (P