The role of the microbiome in the gastrointestinal colonization with carbapenemase-producing Klebsiella pneumoniae. mouse gut metagenome

In this study we examine a murine model of gastrointestinal colonization with OXA-162-carbapenemase and CTX-M-15 extended-spectrum beta-lactamase producing Klebsiella pneumoniae following the administration of ampicillin, ceftazidime and ciprofloxacin. We investigated the effects of various antibiotic treatments on the level of gastrointestinal colonization with the carbapenemase-producing Klebsiella, on the amount of detectable resistance genes (CTX-M-15 and OXA-162), the horizontal gene transfer, and on the composition dysbiosis and diversity of the microbiome by analysing the feaces