DNA methylation of peripheral blood cells of CKD patients.

The relationship between DNA methylation changes in peripheral blood cells of CKD and ESKD patients and both DNA damage in renal constituent cells and fatty liver remains unclear. In this study, we analyzed DNA methylation changes in peripheral blood cells of CKD and ESKD patients and examined their associations with DNA damage levels in urinary exfoliated cells and HSI (Hepatic steatosis index). DNA methylation analysis was performed using EPIC array to examine methylation changes in peripheral blood cells of CKD and ESKD patients, and investigate their associations with DNA damage levels in urinary exfoliated cells and HSI (Hepatic steatosis index).