Hits identified from the LOPAC1280 library screening in the Y. pestis induced NF-κB assay.
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*The two compounds potentiated Y. pestis induced NF-κB activation, which was due to their interference in the signal channel.**Compound parthenolide is classified as belonging to the serotonin class in the LOPAC library. Published studies by Saadane et al[29] reveal that parthenolide is an IκB kinase inhibitor and hence included in the phosphorylation target class.
创建时间：
2015-12-02
