ADRB2 haplotype analysis comparing obesity and hypertension status among 5,838 and 5,584 individuals from the Inter99 study sample, respectively.

Haplotype frequencies were estimated using the expectation-maximization (EM) algorithm and association was evaluated by global and haplotype-specific score statistics (Schaid et al.2002). The global p-value is an estimate for the overall effect of haplotypes in the statistical model and the specific p-value is an estimate of the effect of a specific haplotype compared to the effect of the remaining haplotypes combined. Obesity status was examined as individuals having a BMI below 25 kg/m2 vs. individuals having a BMI above 30 kg/m2. Hypertension status was examined as mean systolic blood pressure��140 mm Hg and/or mean diastolic blood pressure��90 mm Hg and/or current or previous treatment with antihypertensive drugs vs. normotensive individuals.