Silver(I)-Catalyzed Regioselective Construction of Highly Substituted α‑Naphthols and Its Application toward Expeditious Synthesis of Lignan Natural Products
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https://figshare.com/articles/dataset/Silver_I_Catalyzed_Regioselective_Construction_of_Highly_Substituted_Naphthols_and_Its_Application_toward_Expeditious_Synthesis_of_Lignan_Natural_Products/2203234
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资源简介：
A novel route has been developed
for regioselective synthesis of
highly substituted α-naphthols, binaphthols, and anthracenol
through silver(I) catalyzed C(sp3)–H/C(sp)–H,
C(sp2)–H/C(sp)–H functionalization of β-ketoesters
and alkynes, respectively, in a single step using water as a solvent.
This protocol exhibited broad substrate scope and paved the way for
synthesis of anticancer arylnaphthalene lignan natural products such
as diphyllin, taiwanin E, and justicidin A with excellent selectivity.
创建时间：
2016-02-15
