Comparison of mother and infant groups with respect to HLA concordance, homozygosity, allele frequency and protective alleles.

a: TR (Transmitting mothers; N = 68–74); NT (Non-transmitting mothers; N = 143–150); IP (Intrapartum-transmitting mothers; N = 28–29); IU (Intrauterine-transmitting mothers; N = 19–21).b: INF (Total infected infants; N = 70–72); EU (Exposed-uninfected infants; N = 149); IP (Intrapartum-infected infants; N = 28); IU (Intrauterine-infected infants; N = 20).c: Results are shown only for alleles where trends or significant differences were noted in either group (i.e. mothers and/or infants).d: Protective alleles are HLA-B*57:02, HLA-B*57:03, HLA-B*58:01 and HLA-B*81:01. In the genotypic comparisons the individual was scored once for possession of at least one protective allele.(i.e. if homozygous for protective allele was only scored once) and denominator was the number of individuals. In the allelic comparisons the number of alleles were scored and the denominator would be the total number of alleles (i.e. accounts for allelic dose of a protective allele).-: Not applicable since concordance looks at mother-infant pairs.ND: Not determined.Bold P values indicate trends (0.05PP