Synthesis of α‑Functionalized Trichloromethylcarbinols
收藏NIAID Data Ecosystem2026-03-08 收录
下载链接：
https://figshare.com/articles/dataset/Synthesis_of_Functionalized_Trichloromethylcarbinols/2134771
下载链接
链接失效反馈官方服务：
资源简介：
A new
series of α-functionalized trichloromethylcarbinols
have been synthesized from corresponding α-halomethyl ketones,
esters, and amides in 48–78% overall yields. Reactivity of
nitrates obtained in the first step was dependent on the electron-withdrawing
nature of the functional groups, and increases with increasing electron
deficiency. Synthetic applications of such trichloromethylcarbinols
for the preparation of chloromethyl-α-diketones, trichloromethylated
dihydrofurans, and enol acetates of α-functionalized acid chlorides
have been demonstrated. The reaction of these compounds in the Jocic-Reeve
reaction was also demonstrated.
创建时间：
2016-02-13
