Activation of RXRa reprograms chromatin accessibility to protect against acute kidney injury [RNA-seq]

Purpose: To explore whether the differences in chromatin openness correlate with distinct gene expression in PTCs of MI and SI Methods: Proximal tubules were isolated for RNA-seq Results: Using an optimized data analysis workflow, we mapped reads to the mouse genome (mm10). Approximately 2%-13% of the transcripts showed differential expression within the different groups, with a fold change >= 1.5 and p value <0.05. Overall design: RNA-sequencing of different conditions: Sham and bilateral ischemia-reperfusion injury (bIRI) mice with or without bexoratene