Data of a series of novel chiral biaryl monophosphonates

Herein, we report a highly efficient organocatalytic asymmetric arylation of p-quinone phosphonates and 2-naphthols. A series of chiral biaryl monophosphonates were obtained under mild conditions in excellent yields and enantionselectivities (up to 99% yield and 95% ee). This reaction is highly functional group tolerant and could be operated at gram scale with a low catalyst loading (0.5 mol %). Remarkably, our approach provides a green and readily access to novel chiral biaryl monophosphorus ligands. Compound 4ca was successfully converted to novel chiral biaryl monophosphorus ligands 7a, 7b and 8 with high enantionselectivities in three steps.

本研究中，我们报道了一种高效的对映选择性有机催化芳基化反应，该反应涉及对-醌基磷酸酯和2-萘酚。在温和的条件下，我们以优异的产率和光学选择性（高达99%的产率和95%的ee值）合成了系列手性双芳基单磷酸酯。该反应对官能团具有极高的耐受性，并且可以在克级规模下进行，催化剂负载量低（0.5摩尔%）。值得注意的是，我们的方法提供了一种绿色且易于获取的新型手性双芳基单磷配体。化合物4ca成功地通过三步反应转化为了新型手性双芳基单磷配体7a、7b和8，且具有高的光学选择性。