Site-specific tests for positive selection on different IFITM sub-families.

lnL, the log-likelihood difference between the two models; 2Δl, twice the log-likelihood difference between the two models; NA, not allowed; NS, not shown (it means the sites under positive selection but not reaching the significance level of 0.9). The positively selected sites were identified with posterior probability ≥0.9 using Bayes empirical Bayes (BEB) approach. One asterisk indicates posterior probability ≥0.95, and two asterisks indicate posterior probability ≥0.99. Codon positions from top to bottom are according to the sequences of human IFITM3, human IFITM1, human IFITM3, marmoset IFITM-like1, mouse IFITM3, frog IFITM10, human IFITM10 and human IFITM5, respectively. Reference sequences can be found in Figure S5.athe positively selected sites were identified with posterior probability ≥0.8.