Interferon antagonism by SARS-CoV-2: a functional study using reverse genetics
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https://www.omicsdi.org/dataset/bioimages/S-BSST525
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Background
The COVID-19 agent, SARS-CoV-2, is conspecific with the severe acute respiratory syndrome coronavirus (SARS-CoV) that caused SARS in 2002. Whereas both viruses share a completely homologous repertoire of proteins and use the same cellular entry receptor, their transmission efficiencies and pathogenetic traits differ. Here, we studied differences in dsRNA abundance and IRF-3 nuclear translocation in SARS and SARS-CoV-2 infected Calu-3 cells under untreated conditions or after treatment with Ruxolitinib, a JAK-STAT-inhibitor, and Camostat Mesylate.
创建时间：
2023-02-22
