RNA-sequence on prostates of wild type (C57BL/6J) and ARNoC/Y mice that underwent orchidectomy and testosterone (or vehicle) replacement for 4 days

We generated a mouse model (ARNoC/Y) with a mutation in the FQNLF motif located on the aminoterminal domain (NTD) that disrupts the N/C interactions of the androgen receptor (AR). These mice exhibit a normal male phenotype. To be able to compare WT males and ARNoC/Y mice more directly, we performed a castration experiment with testosterone (T) supplementation for 4 days. Since slightly differences in prostate weight were observed, we performed RNA-seq on these prostate to evaluate the biological relevance. Overall design: Sample = ventral prostate; 5 samples per group: WT + vehicle, WT + testosterone, ARNoC/Y + vehicle, ARNoC/Y + testosterone