Demethylase KDM4C binds KLK2 and KLK3 promoters

Phosphorylation of histone 3 at threonine residue T12 (also labeled in literature as T11) by PKN1 enables recruitment of demethylase KDM4C (JMJD2C) to trimethylated histone 3 at KLK2 and KLK3 promoters (Metzger et al. 2008). KDM4C specifically binds to trimethylated lysine residues (Whetstine et al. 2006).

组蛋白3在苏氨酸残基T12（亦在文献中被标记为T11）的磷酸化，由PKN1介导，可促进去甲基化酶KDM4C（JMJD2C）结合至KLK2和KLK3启动子处的三甲基化组蛋白3，此过程由Metzger等人在2008年所描述。KDM4C特异性地结合至三甲基化赖氨酸残基（Whetstine等人在2006年报道）。