Pharmacokinetics of DB844 and DB820 in vervet monkeys after the 14th oral dose at 6 mg/kg (n = 7).

Key: Values are geometric mean (90% CI) except for metabolite∶parent AUC ratio and Tmax, which are reported as median (range). Metabolite∶parent AUC ratio was derived using the AUC from time zero to the last common time point for DB844 and DB820.;*% AUC extrapolated to infinite time >25%.†Duration of sample collection was insufficient to derive an accurate estimate of terminal half-life; AUC(0-∞), AUC from zero to infinite time; AUClast, AUC from time zero to the last measurable concentration; Cl/F, apparent (oral) clearance; Cmax, maximum concentration; t1/2, terminal half-life; Tmax, time to reach Cmax; NA, not applicable; NC, not calculable.