Abnormal findings in cytogenetic and FISH analysis performed on twenty-one independently derived hNPC lines.

*- Cytogenetic G-band karyotyping results with the percent abnormal based on analysis of 20 metaphase cells, ? - FISH analysis results showing the percent of cells displaying either trisomy 7 (+7) or trisomy 19 (+19) based on counting signals in at least 200 nuclei. Normal results from a cytogenetic or FISH study are stated. Tests that were not performed are represented by ��NP�� in the relevant column. Whenever an aberration was detected, the absolute number or the range of per cent abnormal cells from passage to passage is indicated.�� - The results for multiple passages from one line or its derivatives tested are listed in different rows.# - The passage range in a row indicates testing of the line or its derivative at different passages.? - Five out of 21 lines were identified as susceptible to +7 and only M031 CTX was identified with +19.��- B001 and B003 CTX lines were obtained from Down's syndrome patients that present with a trisomy 21 (+21).