GenBank

GenBank® is a comprehensive database that contains publicly available nucleotide sequences for almost 260 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assigns accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP.

GenBank® 是一个包含近 260,000 个正式描述物种的公开核苷酸序列的综合性数据库。这些序列主要通过来自单个实验室的提交以及大规模测序项目（包括全基因组鸟枪法测序（WGS）和环境采样项目）的批量提交获得。大多数提交使用基于网络的 BankIt 或独立运行的 Sequin 程序进行，GenBank 工作人员会在收到数据后分配存取号。与欧洲核苷酸档案（ENA）和日本 DNA 数据库（DDBJ）的每日数据交换确保了全球覆盖。GenBank 通过 NCBI Entrez 检索系统提供访问，该系统整合了主要 DNA 和蛋白质序列数据库的数据，以及分类学、基因组、图谱、蛋白质结构和结构域信息，以及通过 PubMed 提供的生物医学期刊文献。BLAST 提供了 GenBank 及其他序列数据库的序列相似性搜索。GenBank 数据库的完整双月发布和每日更新可通过 FTP 获取。