Data for: Pro-Inflammatory response to macrotextured silicone implant wear debris

Macrotextured silicone breast implants are associated with several complications, ranging from seromas and hematomas to the formation of a rare type of lymphoma, known as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The presence of silicone wear debris has been detected within the peri-implant region and fibrotic capsule and histological analyses reveal inflammatory cells surrounding debris particles. However, it is unclear how these debris particles are generated and released from macrotextured implant surfaces, and whether wear debris generation is related to implant stiffness. In this study, we created an accelerated implant aging model to investigate the formation of silicone wear debris produced from self-mated (“shell-shell”) tribological interactions. We created implant-like silicone elastomers from polydimethylsiloxane (PDMS) using Sylgard 184 base:curing agent (10:1, 12:1, and 16:1) and quantified their mechanical properties (E* = 1141 ± 472, 336 ± 20, a..., , , # Data for: Pro-Inflammatory response to macrotextured silicone implant wear debris

[https://doi.org/10.5061/dryad.m37pvmdcw](https://doi.org/10.5061/dryad.m37pvmdcw)

Atkins, D.J., Rogers, A.E., Shaffer, K.E. *et al.* Pro-Inflammatory Response to Macrotextured Silicone Implant Wear Debris. *Tribol Lett* **73**, 30 (2025). [https://doi.org/10.1007/s11249-025-01965-6]()

Corresponding author: Angela Pitenis, [[e-mail]](mailto:[e-mail])

## Description of the data and file structure

### Files and variables

The compressed folder **2025_Atkins_TribLett_DataDryad.zip** contains images and the data to reproduce the figures from the associated manuscript.

A) Figure2a_representative_indentation_curves.csv

\* row 1: labels for column data with units

\* row 2 and beyond: data

\* column 1: implant sample z-stage position, in micrometers, the x-axis of the force-indentation plot

\* column 2: implant sample normal force, Fn, in micro-Newtons, the y-axis of the force-indenta...