List of main plasma metabolites found in mice over a 33-day study period.

Arrows indicate significantly changing substances comparing plasma of E. caproni-infected mice with non-infected control mice (↑, increased; ↓, decreased in infected animals) and the numbers in brackets indicate the day of maximum significance. *glucose was the only metabolite found, which changed its directionality with time, i.e., it increased significantly after one day of infection and at day 12 post-infection was present in significantly lower concentrations, compared to uninfected control mice. The p-values for the changing metabolites were assessed using a non-parametric 1-way analysis of variance (Mann-Whitney U) test in MATLAB, based on the integrals of the selected peaks and were all in the range of 0.001 to 0.05.