IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
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In the endoplasmic reticulum (ER) lumen, multiple inositol polyphosphate phosphatase 1 (MINPP1) dephosphorylates 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1,2,4,5,6-pentakisphosphate (I(1,2,4,5,6)P5) (Caffrey et al. 1999, Chi et al. 1999, Deleu et al. 2006, Nogimori et al. 1991).
在粗面内质网(ER)腔室中,多种肌醇多磷酸磷酸酶1(MINPP1)通过去磷酸化1,2,3,4,5,6-己磷酸(IP6)生成肌醇1,2,4,5,6-五磷酸(I(1,2,4,5,6)P5)(参见Caffrey等,1999年,Chi等,1999年,Deleu等,2006年,Nogimori等,1991年研究)。
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