Epigenetic modules governing skin epidermal homeostasis [Dlx3 WT and KO primary cells]

Skin homeostasis is guided by spatiotemporal regulation of gene expression, establishing each stage of keratinocyte differentiation. The current study presents transcriptomic and chromatin profiling for the proliferating (basal) and differentiated (suprabasal) cell populations derived from neonate mice (p0-p2) skin epidermis. This multi-omic approach will enable idenitification of cell specific epidermal cross-talk central to the equlibirum. Overall design: Transcriptomic profiling for adeno-virus transduced (either Ad-GFP or Ad-Dlx3) primary cells cultured from transgenic Dlx3 wild-type and knock-out pups (p0-p1)