Supplementary table 1,2.docx

Urinary extracellular vesicles (uEVs) present a new method to study ADTKD-HNF1β pathophysiology in the kidney, as alternative for kidney biospsies. Enrichment of pathways involved in cytoskeletal organization and cilia in the uEV proteome of patients with ADTDK-HNF1β compared to CKD, which may indicate the presence of renal cysts. In this, we show that ADTKD-HNF1β more closely resembles ADPKD. Altogether, the uEV proteome captures the biological changes that are caused by pathogenic variants in HNF1β.