X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera
收藏Protein Data Bank Japan2024-11-20 更新2026-04-19 收录
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X-ray crystal structure of JRD-SIK1/2i-3 bound to a MARK2-SIK2 chimera Descriptor: DI(HYDROXYETHYL)ETHER, N-[(5P,8R)-5-(2-cyano-5-{[(3R)-1-methylpyrrolidin-3-yl]methoxy}pyridin-4-yl)pyrazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide, SULFATE ION, ... Authors: Raymond, D.D, Lemke, C.T, Shaffer, P.L, Collins, B, Steele, R, Seierstad, M. Deposit date: 2023-08-24 Release date: 2024-01-10 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. Proc.Natl.Acad.Sci.USA, 121, 2024
创建时间：
2023-08-24
