BIOGRID CURATED DATA FOR MOM-1 (Caenorhabditis elegans)

Protein-Protein, Genetic, and Chemical Interactions for MOM-1 (Caenorhabditis elegans) curated by BioGRID (https://thebiogrid.org); DEFINITION: mom-1 encodes a putative O-acyltransferase orthologous to Drosophila PORCUPINE and human PORCN (OMIM:300651, mutated in focal dermal hypoplasia); MOM-1 functions as part of a Wnt/MAPK signaling pathway required maternally for endoderm induction in the early embryo; by orthology, MOM-1 is predicted to be a membrane-spanning endoplasmic reticulum protein that stimulates post-translational processing of Wnt signaling molecules such as MOM-2; embryonic mosaic analysis indicates that MOM-1 activity is required in the signaling cell, P2, for proper specification of endoderm, consistent with its predicted role in processing MOM-2/Wnt.

MOM-1（秀丽隐杆线虫Caenorhabditis elegans）的蛋白质-蛋白质、遗传和化学相互作用数据集，由BioGRID（https://thebiogrid.org）整理；定义：mom-1编码一种假定的O-酰基转移酶，与果蝇PORCUPINE和人类PORCN（OMIM:300651，突变会导致局灶性真皮发育不良）同源；MOM-1作为Wnt/MAPK信号通路的一部分，在早期胚胎的内胚层诱导过程中发挥母系功能；根据同源性，预测MOM-1是一种跨膜内质网蛋白，能够刺激Wnt信号分子如MOM-2的翻译后加工；胚胎镶嵌分析表明，MOM-1活性对于信号细胞P2的适当内胚层指定是必需的，与其在MOM-2/Wnt加工中的预测角色相一致。