Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer (ATAC-seq)

We present paired ATAC and RNA-sequencing from EGFR-driven lung cancer cell lines genetically modified to lose tumor suppressors RB1 and/or PTEN, and study the acute response of these cell lines to FDA-approved chemical inhibitors of EGFR Examination of chromatin accessibility and transcriptome following genetic and/or chemical perturbation of lung cancer cells