Prerequisite endocardial-mesenchymal transition for cardiac trabecular angiogenesis
收藏Alliance of Genome Resources2026-08-01 收录
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We used single cell RNA sequencing (scRNAseq) to show that ventricular endocardial cells generate trabecular vessels through an angioEMT mechanism. We did E12.5, E13.5, E14.5 and E15.5 whole heart scRNAseq and intergated these 4 stage data together. We analyzed endothelial cell clusters and compared different subclusters in a stage-dependent diffence within subclusters, to find the potential mechanism of how ventricular endocardial cells generate trabecular vessels.
