Organocatalytic Synthesis of 4‑Aryl-1,2,3,4-tetrahydropyridines from Morita-Baylis-Hillman Carbonates through a One-Pot Three-Component Cyclization

An
efficient DABCO-catalyzed three-component formal [3 + 2 + 1]
annulation, involving a Morita-Baylis-Hillman carbonate, a 1,3-ketoester,
and a primary amine, leading to one-pot synthesis of substituted 4-aryl-1,2,3,4-tetrahydropyridines,
has been developed. The densely functionalized products were generally
obtained in good to excellent yields under mild conditions. The structures
including the relative stereoconfigurations of the representative
products were confirmed by X-ray diffraction analysis.