Gene array analysis of anaplastic thyroid carcinoma cell lines versus normal thyroid cell lines. Homo sapiens

Currently there is a lack of effective therapies which result in long-term durable response for patients presenting with anaplastic thyroid carcinoma (ATC), a very rare and lethal variant of thyroid cancer. ATC is resistant to chemotherapy, radiation, and targeted therapies currently available. In an effort to identify novel tumor-specific therapeutic targets, we performed high throughput gene array analysis screening numerous ATC cell lines, and compared their gene expression levels to normal thyroid cell lines. Overall design: RNA was extracted from Anaplastic Thyroid Cancer cell lines and Normal Thyroid cell lines. Gene array analysis was performed, and resulting expression levels were compared between Normal and ATC samples