WIDDE

This next generation database is dedicated to the storage and management of dense genotyping data sets (up to several hundreds of thousands markers genotyped on thousands of individuals). It includes several utilities to select (on a population and/or marker location basis) data subsets, to perform basic data quality check and standard population genetics analyses (test of Hardy-Weinberg equilibrium, Principal Component Analysis) and to export the resulting datasets in various popular formats. Users can also upload their own genotyping data and explore them with data stored in WIDDE and assign new individuals to WIDDE populations using distance-based method and supervised hierarchical clustering. WIDDE contains public (freely accessible) and private (accessible via a login and password) data. The current version features cattle and sheep data but expect more to come!这款下一代数据库专为高密度基因分型数据集（可对数千个个体完成多达数十万个遗传标记的基因分型）的存储与管理而打造。其内置多款实用工具，可基于群体及/或标记位点筛选数据子集、执行基础数据质量控制与经典群体遗传学分析——包括哈迪-温伯格平衡（Hardy-Weinberg equilibrium）检验、主成分分析（Principal Component Analysis），并可将生成的数据集导出为多种主流格式。用户还可上传自有基因分型数据，与WIDDE存储的数据集联合开展探索性分析，同时可通过基于距离的方法与有监督层级聚类（supervised hierarchical clustering），将新个体划归至WIDDE的已有群体中。WIDDE涵盖公开（可免费获取）与私有（需通过账号密码访问）两类数据。当前版本搭载牛与绵羊的基因分型数据，后续将新增更多物种的相关数据！

搜集汇总

背景与挑战

背景概述

WIDDE是一个专为存储和管理密集基因分型数据设计的下一代数据库，支持数据子集选择、质量检查、标准群体遗传学分析及多格式导出。用户可上传自有数据与库内数据整合分析，数据库包含公开和私有数据，当前版本主要涵盖牛和羊的遗传多样性数据，并计划扩展更多物种。