Il-17 p53 Developmental Series

Here, we show that the activity of the tumor suppressor p53 in the metazoan C. elegans switches organismal development between reproductive growth and dormancy by responding to nutrient availability signaled by the cytokine, ILC-17.1. ILC-17.1-dependent repression of the C. elegans p53 ortholog CEP-1 is required for larval growth and development; ILC-17.1 deficiency activates CEP-1/p53 in post-embryonically dividing progenitor blast cells, decreases glucose utilization and cytochrome C levels, upregulates cell cycle inhibitors, and causes larvae to arrest as stress-resistant, quiescent dauers. Comparative gene expression profiling analysis of RNA-seq data at two different developmental time points(15 hrs and 32 hrs) of C. elegans larvae in the following gennotypes wild type (N2), ilc-17.1(syb5296) X,unc-119 (ed4); gtIs1 [CEP-1::GFP + unc-119 (+)],ilc-17.1 (syb5296)X; cep-1 (gk138) I