ACSS2 alleviates alcoholic liver disease via modulating hepcidin-mediated systemic iron homeostasis and hepatic ferroptosis

Alcoholic liver disease (ALD) is one of the most prevalent types of liver disease associated with high morbidity and mortality, caused by hepatotoxicity originating from alcohol metabolism, but current therapeutic drugs are still limited. The role of ACSS2 as an enzyme that metabolizes acetate in ALD remains unknown. Our study aimed to investigate the function of ACSS2 and its potential mechanism in ALD progression. Overall design: To explore the function of ACSS2 in alcoholic liver disease, hepatocyte-specific knockout mice were generated and the liver transcriptome analysis was performed