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A Depolarization-Activation Strategy Targeting Microglia: Cuproptosis-Mediated Immune Re-sensitization Nanoplatform in Glioma Therapy

Name: A Depolarization-Activation Strategy Targeting Microglia: Cuproptosis-Mediated Immune Re-sensitization Nanoplatform in Glioma Therapy
Creator: Zhongshan Hospital, Fudan University
Published: 2026-02-22T16:48:30+08:00

integrated proteome resources2026-02-28 收录

胶质瘤免疫治疗

铜死亡机制

数据链接：

https://www.iprox.cn/page/project.html?id=IPX0015840000 数据链接链接失效反馈

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资源简介：

A Depolarization-Activation Strategy Targeting Microglia: Cuproptosis-Mediated Immune Re-sensitization Nanoplatform in Glioma Therapy

应用场景：

提供机构：

Zhongshan Hospital, Fudan University

创建时间：

2026-02-22

癌症预后生物标志物

铜死亡机制

BackgroundThe mechanism of cuproptosis has recently been reported in lipoylated proteins of the tricarboxylic acid (TCA) cycle. Besides, the role of copper was previously recognized in cancer progress

NIAID Data Ecosystem40

Data_Sheet_1_Impact of Radiochemotherapy on Immune Cell Subtypes in High-Grade Glioma Patients.PDF

胶质瘤免疫治疗

放化疗免疫效应

Glioblastoma is a dreadful disease with very poor prognosis, median overall survival being <2 years despite standard-of-care treatment. This has led to the development of alternative strategies, among

NIAID Data Ecosystem30

Table_1_An Immune Gene-Related Five-lncRNA Signature for to Predict Glioma Prognosis.DOCX

胶质瘤免疫治疗

RNA预后模型

BackgroundThe tumor immune microenvironment is closely related to the malignant progression and treatment resistance of glioma. Long non-coding RNA (lncRNA) plays a regulatory role in this process. We

NIAID Data Ecosystem20

Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin). Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin)

胶质瘤免疫治疗

药物协同作用

drugs targeting mitosis might affect the tumor microenvironment and sensitize cancer cells to immunotherapy. BAL101553 monotherapy increased survival in immune checkpoint blockade–resistant SB28 gliob

NIAID Data Ecosystem40

Table_1_Optimization of cancer immunotherapy through pyroptosis: A pyroptosis-related signature predicts survival benefit and potential synergy for immunotherapy in glioma.xlsx

胶质瘤免疫治疗

细胞焦亡预后模型

BackgroundPyroptosis is a critical type of programmed cell death that is strongly associated with the regulation of tumor and immune cell functions. However, the role of pyroptosis in tumor progressio

NIAID Data Ecosystem30

A Depolarization-Activation Strategy Targeting Microglia: Cuproptosis-Mediated Immune Re-sensitization Nanoplatform in Glioma Therapy

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