Finite element results (archive): high RyR density, with mitochondria

Results from a reaction-diffusion finite element model of calcium signalling in a rat ventricular cardiomyocyte. Solved for the first 30 ms of the calcium transient in an 8 sarcomere section.Calcium is released from RyR clusters with spacings based on immuno-labeled microscopy data populations (123 clusters per z-disk). Regions representing mitochondria are excluded to produce barriers to diffusion in the intracellular space.To view the results of the calcium and fluorescence-bound calcium fields, visualisation of the results in the 'vtk' folder with ParaView is recommended. All field data is available in OpenCMISS exnode / exelem formats in the 'output' folder. Note this model was run on 8 parallel processes.

本研究呈现了一项基于反应-扩散有限元模型构建的鼠室性心肌细胞钙信号传递结果。模型针对钙瞬变前30毫秒内的首个8个肌节部分进行求解。钙离子从基于免疫标记显微镜数据（每123个z盘为一组）分布的RyR簇中释放。为在细胞内空间中制造扩散障碍，代表线粒体的区域被排除在外。建议使用ParaView软件在'vtk'文件夹中可视化钙离子和荧光结合钙离子的场分布结果。所有场数据均以OpenCMISS exnode / exelem格式存储于'output'文件夹中。请注意，该模型是在8个并行进程中运行的。