A Gradient Boosting Framework for Six-Stage Hepatitis B Virus Disease Staging with Youden-Optimized Biomarker Thresholds: A Multicenter Validation Study

This dataset contains code, processed clinical data and analytical outputs for MDTOS, a LightGBM hierarchical machine learning framework optimized via Youden’s J index for six-stage non-invasive hepatitis B virus disease staging, validated across multi-center Chinese cohorts, NHANES and the independent REVEAL-HBV population.