Coding mutations observed in the HCV envelope proteins.

Mutations were found by direct sequence analysis of RT-PCR from recovered viruses. Red columns denote mutations observed to mediate low-level resistance against both AR3A and AR5A. Blue columns denote mutations shown to be involved in mediating specific high-level resistance against AR5A. *The mutation was dominant, but a minor a peak of the original nucleotide was observed. **The following amino acids were observed: HLYNRSIQTVPGK. §Data was taken from Los Alamos on 28th of December 2016. Of note, most isolates presented in the database are genotype 1, potentially skewing the results. -, No additional amino acids observed across genotypes.