Expression data from mice mammary glands from Elf5 knockout (KO) and wildtype controls

We developed conditional knockout mice where the transcription factor Elf5 (also called ESE-2) is deleted in the mammary glands. Loss of Elf5 results in block in alveologenesis and epithelial differentiation defects. Mammary gland samples from Elf5 knockout and wild type animals were analyzed for global transcriptome changes. We used microarrays to performing transcriptional profiling of Elf5KO and control mammary glands at Lac1 (Lactation day 1)我们构建了条件性基因敲除小鼠模型，其中转录因子Elf5（亦称ESE-2）可在乳腺组织中被特异性敲除。Elf5的缺失会导致乳腺肺泡发生受阻以及上皮细胞分化异常。我们对Elf5敲除型与野生型动物的乳腺组织样本进行了分析，以检测其全转录组水平的表达变化。我们采用微阵列技术，对泌乳第1天（Lac1）的Elf5敲除型与对照乳腺组织进行了转录谱分析。