Expression data from RCC cell lines to study metastasis progression. Homo sapiens

This study investigates the molecular signatures that drive Renal Cell Carcinoma (RCC) metastatic conversion using the metastatic (LM2) and non-metastatic (SN12C) RCC cell lines. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. Overall design: To identify differences in gene expression associated with increasing metastatic activity, we subjected the three RCC cell types, SN12C, LM1, LM2 to gene expression profiling.