Computationally predicted minimal perturbations sets (MIS) required for transitioning TEM regulatory network into highly or weakly pro-angiogenic TEM.

These two final desired cell steady states were obtained by assigning to TIE-2 and VEGFR-1 nodes a fixed polarity of either both high (highly pro-angiogenic i.e tumor TEM) or low (weakly proangiogenic i.e. blood TEM) expression levels. Computationally predicted MIS decreasing TEM pro-angiogenic activity were classified in three groups based on the receptor tyrosine kinase (RTK) inhibited and inflammatory (TGF-β or TNF-α) and angiogenic ligands up-regulated. Computationally predicted minimal perturbations sets (MIS) required for transitioning TEM regulatory network into highly or weakly pro-angiogenic TEM.