HPTN 040/P1043 Medical and Obstetric History Primary Dataset in Phase III Randomized Trial of the Safety and Efficacy of Three Neonatal Antiretroviral Regimens For Prevention Of Intrapartum HIV-1 Transmission

Whether the mother received any prenatal care, number of prenatal care visits, if any hospitalizations occurred during pregnancy, and general obstetric history (including current pregnancy and delivery)
Study Description
Compared the efficacy and safety of three antiretroviral regimens [standard zidovudine (ZDV) regimen vs. ZDV and nevirapine (NVP) vs. ZDV, lamivudine (3TC) and nelfinavir (NFV)] administered for the prevention of vertical HIV-1 transmission to infants born to HIV-1-infected women who did not receive antiretroviral therapy during the current pregnancy. Primary outcome measure was HIV-1 infection at 3 months in infants uninfected at birth. This study was conducted by the National Institute of Allergy and Infectious Diseases (NIAID) HIV Prevention Trials Network (HPTN). Biospecimens are available. HIV positive women (n=1724) in Argentina, Brazil, South Africa, and the U.S. who did not receive antiretroviral therapy during pregnancy and their newborn infants (n=1745); race and ethnicity data below are for mothers only