Diastereoselective Synthesis of δ-Aminoacids through Domino Ireland−Claisen Rearrangement and Michael Addition
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https://figshare.com/articles/dataset/Diastereoselective_Synthesis_of_Aminoacids_through_Domino_Ireland_Claisen_Rearrangement_and_Michael_Addition/2941963
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资源简介：
A novel domino reactionstereoselective Ireland−Claisen rearrangement and asymmetric Michael additionis described. A protocol starting from Baylis−Hillman adducts 3a−f using chiral lithium amide affords optically active γ-substituted δ-aminoacids 4a−f with high diastereoselectivities and enantioselectivities. The acid can be isolated easily from large-scale reactions and transformed to 2,3-disubstituted piperidines 11 or 2-substituted nipecotic acid derivates 12.
创建时间：
2016-02-27
