Impact of 3-amino-1,2,4-triazole (3-AT)-derived increase in hydrogen peroxide levels on inflammation and metabolism in human adipocytes

Obesity is a multifactorial
disease associated with oxidative stress and chronic inflammation and
characterized by an excessive accumulation of fat in adipose tissue. Excessive
H2O2 levels are degraded by catalase, whose activity is
decreased in obesity. We
investigated the effects of inhibition of catalase activity by
3-amino-1,2,4-triazole (3-AT) on the metabolism and inflammation of human differentiated adipocytes.