Additional file 1 of Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth

Additional file 1: Table S1. Subject characteristics as assessed at the baseline timepoint in youth with the 5 most common C4 structural haplotypes. Table S2. Count and proportion of C4 alleles in the ABCD cohort (1,694 AFR; 5,829 EUR; 2,115 Latinx). Table S3. Summary of PheWAS results in the ABCD cohort. Table S4. Summary of 1-year follow-up PheWAS in the ABCD cohort. Table S5. Summary of 2-year follow-up PheWAS in the ABCD cohort. Table S6. Summary of C4 GREx associations with regional brain surface area in the ABCD cohort. Table S7. Summary of C4 GREx associations with whole brain volume (WBV), mean surface area (SA), and mean cortical thickness (CT). Table S8. Summary of C4 GREx associations with regional brain cortical thickness in the ABCD cohort. Table S9. Summary of C4 GREx associations with subcortical brain volume in the ABCD cohort. Table S10. Summary of Wilcoxon Rank Sum Tests comparing PQ-B symptoms and PQ-B severity at 1- and 2-year follow-up timepoints in youth in the top/bottom quartile for entorhinal cortex surface area at baseline. Table S11. Summary of schizophrenia PRS associations in youth of EUR ancestry. Table S12. Summary of schizophrenia PRS associations with regional cortical thickness in youth of EUR ancestry. Table S13. Summary of schizophrenia PRS associations with regional surface area in youth of EUR ancestry. Table S14. Summary of schizophrenia PRS associations with subcortical volume in youth of EUR ancestry.