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Regulation of TFR cells by Blimp1

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143146
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What genes does the transcription factor Blimp1 regulate in Tfr cells? CD4+ T cells were isolated from the spleen from Wildtype (WT) and Blimp1-flox (Blimp1) Foxp3-cre mice 36 days after 2x oral challenge with peanut + cholera toxin. Cells were isolated via a CD4+ T isolation kit (Miltenyi Biotec). Foxp3+YFP+ CXCR5+ PD1+ cells were further isolated by FACS (FACS Aria). Total RNA was collected from freshly sorted TFR cells using the RNeasy Plus Micro kit (QIAGEN) and subjected to RNA-seq
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2020-01-07
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