Climate footprint of industry-sponsored clinical research: An analysis of a phase-1 randomized clinical study and discussion of opportunities to reduce its impact

Objective: To calculate the global warming potential, in carbon dioxide (CO2) equivalent emissions, from a phase-1 clinical study Design: Retrospective analysis. Data source: Internal data held by Janssen Pharmaceuticals Studies included: Janssen-sponsored TMC114FD1HTX1002 study conducted between 2019-2021 Main outcome: measure CO2 equivalents for trial activities calculated according to IPCC 2021 impact assessment methodology Results: The CO2-eq emissions generated by the trial was 17.65 tonnes. This is equivalent to the emissions generated by driving the average petrol-fueled family car 71,004km or roughly 1.8 times around the circumference of the Earth. Commuting to the clinical site by the study patients generated the most emissions (5,419kg, 31% of overall emissions), followed by trial site utilities (2,725kg, 16% of overall emissions), and Janssen site staff travel (2,560kg, 15% of overall emissions). In total, the movement of people (patient travel, Janssen site staff travel, and..., Lifecycle assessment performed according to ISO 14044 standards and peer reviewed by a third party., , # Climate Footprint of Industry-Sponsored Clinical Research:An Analysis of a Phase-1 Randomized Clinical Study and Discussion of Opportunities to Reduce Its Impact

Dataset includes foreground data collected for the following elements of the clinical trial:

* Information tab: General information over the file
* Patient journey & nutrition tab: Foreground data on patient travel to and from the clinical site as well as meals served to patients during the in-patient care phase of the clinical study
* Drug product tab: Foreground data for the drug product manufactureprocessing of laboratory samples (Samples)
* Testing kits & consumables tab: Foreground data on the testing kits & consumables used at the clinical site
* Samples tab: Foreground data on the processing of laboratory samples
* Utilities commutes & meetings tab: Foreground data on the utilities used at trial site impacts and clinical trial management, commutes at trial site, J&J facilities and ethi...