Low-rank modal decomposition endpoints of beat-resolved retinal arterial Doppler holography waveforms during flicker provocation

This dataset supports the analysis of flicker-evoked neurovascular coupling in beat-resolved retinal arterial blood-flow velocity waveforms measured by ultrahigh-speed laser Doppler holography. One eye of a healthy volunteer was recorded using a Baseline 1/Flicker/Baseline 2 protocol comprising 33 acquisitions: nine during Baseline 1, fourteen during 13-Hz flicker stimulation, and ten during Baseline 2. Each acquisition contained 163,840 retinal interferograms recorded over approximately 4.4 s at approximately 37 kHz. Doppler processing produced approximately 145 velocity maps per second, enabling cardiac-cycle-resolved arterial velocity measurements at multiple locations across the retinal vascular bed. The dataset was acquired to investigate whether flicker stimulation changes not only mean retinal blood flow but also the organization of the arterial pulse waveform. Beat-aligned waveforms can be analyzed using acquisition-level or beat-level singular-value decomposition to derive endpoints describing pulsatile amplitude, dominant-mode expression, residual waveform structure, mean-to-pulsatile balance, and singular-spectrum dimensionality. In this eye, flicker was associated with lower total centered-waveform amplitude and dominant-mode amplitude, together with higher robust residual-amplitude ratios, indicating reduced dominance of the principal arterial pulse waveform.