Berkeley Drosophila Genome Project

The Berkeley Drosophila Genome Project (BDGP) is a consortium of the Drosophila Genome Center, funded by the National Human Genome Research Institute, National Cancer Institute, and Howard Hughes Medical Institute, through its support of work in the Susan Celniker, Ben Brown, and Gary Karpen laboratories. The goals of the Drosophila Genome Center are to finish the sequence of the euchromatic genome of Drosophila melanogaster to high quality and to generate and maintain biological annotations of this sequence. In addition to genomic sequencing, the BDGP is 1) producing gene disruptions using P element-mediated mutagenesis on a scale unprecedented in metazoans; 2) characterizing the sequence and expression of cDNAs; and 3) developing informatics tools that support the experimental process, identify features of DNA sequence, and allow us to present up-to-date information about the annotated sequence to the research community. The information produced in this project is available for download from this page, but the primary method of accessing the annotations is via FlyBase and other similar resources.

伯克利果蝇基因组计划（Berkeley Drosophila Genome Project, BDGP）是果蝇基因组中心（Drosophila Genome Center）下设的科研联盟，由美国国家人类基因组研究所（National Human Genome Research Institute）、国家癌症研究所（National Cancer Institute）及霍华德·休斯医学研究所（Howard Hughes Medical Institute）资助，支持Susan Celniker、Ben Brown与Gary Karpen三个实验室的研究工作。果蝇基因组中心的核心目标是完成黑腹果蝇（Drosophila melanogaster）常染色质基因组的高质量测序，并为该序列生成并维护生物学注释信息。除基因组测序外，BDGP还开展三项核心工作：1）利用P元素介导的诱变技术构建规模空前的后生动物基因敲除突变体库；2）解析互补DNA（complementary DNA, cDNA）的序列与表达特征；3）开发生物信息学工具以支撑实验流程、识别DNA序列功能特征，并向全球科研界提供注释序列的最新动态。本项目产生的相关数据可通过本页面下载，但获取注释信息的主要途径为FlyBase及其他同类科研资源。

搜集汇总

背景与挑战

背景概述

伯克利果蝇基因组计划（BDGP）是一个由多个机构资助的联盟，致力于完成黑腹果蝇基因组的测序并生成生物注释。该项目通过大规模基因破坏、cDNA表征和开发信息学工具来支持研究，其数据可通过FlyBase等资源访问，并将于2026年结束运营。