Single-channel parameters of native If in adult and neonatal cardiomyocytes modulated by KCR1 and KCR1siRNA

Modulation of single-channel parameters of native If (control) by KCR1 overexpression (KCR1-infected) and knock-down of endogenous KCR1 (KCR1siRNA-infected) in adult and neonatal cardiomyocytes. Holding potential −35 mV, test potential −90 mV. Ipeak was measured from ensemble average currents. For closed time and latency analysis, only experiments containing just one detected open level were used for calculation. Numbers of experiments given in parentheses indicate number of experiments with only one channel in the patch. Pooled data are presented as mean±SEM.*p#p